How to get rid of spots overnight. 1. Put down the toothpaste. Most of us have had the odd break-out (Image: Getty). In fact, ignore most DIY. Even though you can't make pimples magically disappear overnight, It's quick and easy, with minimal discomfort, and it usually goes down within a day. Spot treatments can definitely be effective — they help to reduce. This should bring down the swelling, as it slows down blood flow to the area. Either apply . I've got spots on my upper lip and that is the only place I get acne.